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Darlene starts to feel the pressures of her new job which result in a health scare. Meanwhile, Dan attempts to help Ben out at the hardware store but the two don't always see eye to eye on running the business. .
Chuck's new purchase of a boat creates a rift between Dan and his longtime friend. Meanwhile, Darlene hires her first assistant at Wellman's Plastics but soon realizes she is anything but helpful, leading Darlene to question her decision. Elsewhere, Jackie is laser-focused on her dream of being a contestant on "JEOPARDY!" and believes the late, great Alex Trebek wants her to go all the way.
Mark is stressed out and feeling sick, convinced he has COVID-19. Meanwhile, Becky and Harris team up to confront Josh who has been "ghosting" Harris; and when Jackie visits Roseanne's grave, she finds an appalling headstone right next to it and sets out to make it right.
After a sudden turn of events, the Conners are forced to face the daily struggles of life in Lanford in a way they never have before. This iconic family – Dan, Jackie, Darlene, Becky and D.J. – grapples with parenthood, dating, an unexpected pregnancy, financial pressures, aging and in-laws in working-class America. The family prevails through it all – the fights, the coupon cutting, the hand-me-downs, the breakdowns – with love, humor and perseverance.