As Ryan Wilder's Kryptonite wound grows more severe, it hinders Batwoman's ability to protect Gotham. Growing interest in reproducing the serum from the Desert Rose puts Mary's and Commander Kane's lives in danger. Meanwhile, Alice's reunion with a fellow Coryana inhabitant presents unexpected complications.

Batwoman's abilities are tested like never before, while Alice's search for Kate continues; Sophie and Jacob set their sights on Coryana; Luke and Mary contend with an unexpected guest.