A news helicopter reports in on the devastating destruction of Jaku City, with All Might watching on nervously. In the city, Shigaraki is able to efficiently deal with Endeavor and Ryukyu's attacks, while the Heroes attempting to assist are forced to face against the newly awakened "Near High-End Nomu"; Nomu with the strength of a High-End but lacking coherent thoughts. Shigaraki tries to use this opportunity to kill Eraser Head, but Deku suddenly arrives and tackles him, declaring his and Bakugo's intentions to save their teacher. As Endeavor returns to the battle, he agrees to let the two students join in the fight. Shigaraki hopes to try and capture Deku and escape, but in the process, he ends up calling him his "little brother", surprising the two. He realizes that the will of his master still persists within the Quirk, rejecting it and declaring his desire to be better than All For One. The Heroes proceed to overwhelm Shigaraki with their coordinated attacks. Meanwhile at the Villa, Gigantomachia carries the League of Villains members on his back in an attempt to reach Shigaraki; right before he does Dabi nabs Skeptic to take with them, planning to use him for a specific purpose. Mt. Lady is able to barely hold Gigantomachia off, slowing him down while being pushed backward. Midnight attempts to use her Quirk to send the villain back to sleep but is thwarted by the attacks of Dabi and Mr. Compress, which knocks her to the ground, injuring her. She calls on Yaoyorozu and tells her to create anesthetics in order to put the beast to sleep, just as their call is cut off. With the Heroes busy fighting the villains and only the U.A. students remaining, Yaoyorozu takes charge, issuing orders to her classmates as they prepare to intercept Gigantomachia.

To desperately halt the effects of the Quirk-Destroying Drug, Eraser Head cuts his leg off. Despite this, Shigaraki manages to reach his face, slicing one of his eyes, just as Shoto appears, who had been following Deku and Bakugo, blasting him with a mountain of ice, and further knocked back by Deku. With Eraser unconscious, his Quirk is undone, and Shigaraki begins to regenerate all of his injuries. Meanwhile, the evacuation team overhear of the mass destruction caused by Gigantomachia as he makes a reckless beeline directly toward his master; the rest of the U.A. students in Gunga can only look on in fear at the devastation left in his wake. Shigaraki prepares to finish everyone off, only for his body to suddenly split open, realizing that he was awakened too early. Deku figures out that, just like him, his body can't withstand the power of All For One. At this moment, Deku unlocks the Quirk of the 7th user: Nana Shimura's Float, and combined with Blackwhip pulls Shigaraki into the air and rescues his companions. He proceeds to duel Shigaraki in the air alone while the Heroes recover on the ground, causing Bakugo to get anxious. He recalls a conversation with All Might during their training prior where Bakugo voiced his worries regarding a mystery of one of the One For All users, and admitting his bullying of Deku came from not understanding his unselfish and self-sacrifical attitude. While Deku unleashes the full power of One For All to overwhelm Shigaraki, even despite the damage on his body, Bakugo and Shoto get Endeavor into the air, so he can finish him off for good with a Prominence Burn. As he burns alive, All For One's voice calls out to Shigaraki, his body suddenly releasing an array of Rivet Stabs to knock Endeavor away. "Shigaraki" shoots several Rivets out toward Deku, but with no hesitation, just like Deku did for him before, Bakugo blasts forward, pushing him out of the way and getting stabbed instead.