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Mannix's friend Paul Parrish goes to prison for a crime that Mannix doesn't believe he committed, and then kills his former cellmate after he's released.
Mannix wakes up with amnesia of what happened on the previous, and he and Peggy try to recreate where the PI was from the few belongings on his person.
A police detective's wife hires Mannix to find out who wants to kill her husband... but doesn't want the PI to tell her husband who hired him.