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Mohammad, who's 43 and has Motor Neurone Disease, is rushed to St George's with severe sepsis, while 47-year-old David has suffered a significant leg injury.
The first episode in the new series follows two people who have come to the UK and made a home, as well as the story of a woman living with the legacy of cancer.
Mark, who's 32, is rushed to St George's, suffering a head injury due to an epileptic seizure. Anastasia, who's 80, struggles to walk due to severe pain in her leg.