The documentary following life inside an A&E department returns for its first series outside London - at the Queen's Medical Centre, Nottingham. Sister Lou tells her story of working at the hospital for more than 30 years and how her life completely changed in her 50s. Forty-five-year-old Kirsty has been rushed into QMC after an accident at a fun run. The team members carry out extensive tests on 93-year-old John, who is suffering from shortness of breath, and in the children's emergency unit, seven-year-old Hunter is being assessed after falling from a tree.

An 18 year-old is rushed in after suffering a cardiac arrest during a football game and 30 year-old Tom has a severe ankle injury after a head-on traffic collision. In the Minor Injuries department 23 year-old Phoebe has a damaged nose after tripping in the library.