Dr. Sam Griffith fights to keep her new leadership role as chief of surgery when her father and former boss, Dr. Rob "Griff" Griffith, takes his case for reinstatement directly to the hospital board. Also, resident Dr. Caleb Tucker, Sam's ex, forms an unexpected connection to a patient battling a mystery condition.

When Dr. Sam Griffith tracks down a deep-pocketed anonymous hospital donor, she's shocked to discover why the donor is so loyal to her father, Griff. Also, Griff offers to mentor his daughter and assure her succession – if he returns to his role as chief.