In 1990, Florida police were on a frantic search for a killer. Seven men were dead, their bodies scattered along state highways. Terrorized motorists heard of the bullet-ridden victims of the Interstate Killer - but the investigative trail was cold and there was no end in sight. The killer behind the spree was  Aileen Wuornos—a complex, misunderstood misfit who hitchhiked near truck stops, selected her victims at random, and lured them to secluded locations. It took good old-fashioned police work, a little luck, and a lover's betrayal, to finally bring Wuornos' killing spree to an end. This episode features rare interviews with victims' family members, and Wuornos' best friend.

He terrorized Northern California in the late 1960s, killing young couples at secluded lover's lanes. Not satisfied with just the murders, he also taunted the public with cryptic clues, threats of increased violence and most famously, ciphers that were supposed to lead police to his identity, but mostly went nowhere. Detectives, reporters, and even civilians, have worked for decades to solve the case - but so far, no one has succeeded. Can new DNA techniques that were used to catch the Golden State Killer finally unmask this murderer, who is both infamous and completely unknown?