With matters between Danny and Alice still tense, a distracted Danny appears to make a fatal mistake while treating a rare black leopard. When the big cat dies, its arrogant owner demands that Danny be investigated for malpractice. Danny follows his instincts and goes against his suspension to treat Jana who is suffering from renal failure.

There are dangerous consequences when Dup ignores his heart condition and collapses while alone in the bush. Danny and Alice get more than they bargained for when they try to deal with two rogue lions that have been attacking local cattle. Olivia and Caroline struggle with their emotions as the anniversary of Sarah's death draws near.