The Slaton's are larger-than-life sisters who have always relied on each other and food for support. Amy, age 31, is desperate to have children, but hasn't been able to due to her weight. While Tammy, age 32, is one step away from being bedridden.

Amy and Tammy eagerly begin their weight loss journey. Sticking to their diets is a matter of life or death but proves to be a real struggle. The pressure to reach their goals culminates in a huge fight that threatens their diets and relationship.