New evidence of vampiric activity takes Don to Bulgaria, where he joins a vampire hunt and searches for demonic spirits in a dangerous mountain cave. In Hungary he visits the subterranean prison that once held the world's most-famous vampire -- Dracula.

Don visits a sleepy Virginia town where paranormal activity is spiking and finds a connection to the Lost Colony of Roanoke. He retraces the path of a mysterious relic as he explores whether dark magic from the Old World doomed settlers in the New World.