Dan Aykroyd presents Jim and Chris with a hair-brained scheme that sends them deep into the woods of Big Sur, California, in search of a legendary marijuana seed. Meanwhile, Larry investigates a murder on the farm.

Jim and Chris' trip to Mississippi, for their final leg of this part of their national expansion, comes to a halt when they discover their clone plants are sick and in no shape to move onto their next stage of growth. With only 1-2 weeks to fix the issue and nurse the plants back to health, Jim has no choice but to stay back on the farm and send Larry to Mississippi in his place. A decision Chris adamantly disagrees with. Larry has finally started to find his footing in Oregon. But will he buckle under the pressure of walking a mile in Jim's shoes?