For centuries, moonshiners moonlighted as medicine-makers. In that backwoods tradition, three distillers compete to make moonshine that packs a medicinal punch, as Mark, Digger and Tim judge whose jar ultimately tastes the best.

With ingredients in short supply, Mark, Digger and Tim judge the ultimate hard times challenge. Notorious shiners Tickle, Mike and Daniel each bring their own brand of backwoods ingenuity to see who makes the best liquor with unconventional ingredients.