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Following the assassination of a suspect, Clarice and VICAP are investigated by Krendler's rival at the Bureau, SA Anthony Herman. When Ardelia is recruited to assist him, it causes friction between the two friends.
In order to prove to Krendler and the VICAP team that she is fit for duty, Clarice must find the psychological key that will unlock a confession from the suspect in the three river murders.
Clarice is drugged and confined to a hospital bed by a serial killer in the medical profession, causing her to experience intense hallucinations.