A horrific accident leads Daimon and Gabriella fighting to save a man's soul, while a darker force attempts to stop them. Meanwhile, Yen's relationship with his work takes a dark turn towards obsession, and a discovery leads Ana back to St. Teresa's.

A demonic enemy brings together an unusual group. Daimon and Ana travel to San Francisco in search of Yen and an artifact that may help defeat the enemy. Ana tells Daimon about her extracurricular activities, and Gabriella's faith is attacked.