Mel engages in a tense family reunion when she and her disapproving sister race against the clock to save their brother Edison after he's abducted. Also, as the team unravels the motivation behind Edison's kidnapping, Mel grapples with the fallout of her argument with McCall about training Delilah.

When the mother of a patient dying of a rare brain disease holds a hospital hostage in an attempt to get her daughter a lifesaving surgery, McCall races to resolve the situation peacefully while dealing with pushback from government forces.