Lorenzo is once again struggling with her ex, Chiara, when the girl is hospitalized for an overdose. Marco and his wife feel increasingly threatened by the research that Andrea is carrying out on Satonal, the experimental drug that seems to have caused several deaths. Gabriel, on the other hand, has to explain to his community that he plans to stop.

Agnese's conditions worsen rapidly and Andrea finds the support of the whole department to try to discover the disease she suffers from. But the accusations brought against him of his involvement in the falsification of results of a pharmaceutical trials risk take him away from the hospital for good.