Residents of Sunset Park, Brooklyn face rising rents, a legacy of environmental racism and the loss of the industrial jobs that once sustained their community. When a global developer purchases a massive industrial complex on the waterfront and lays plans for an "innovation district," a battle erupts over the future of the neighborhood and of New York City itself.

After losing everything, Desiree Wood takes a second lease on life as a long-haul trucker. Alongside an irreverent group of women drivers, she fights for a life on the road. In a rapidly changing labor landscape, Desiree and her sisterhood of truckers rally against the crushing forces of an industry that is indifferent to their survival.