By the close of the Industrial Revolution, the American food supply was tainted with frauds, fakes, and legions of new and untested chemicals, dangerously threatening the health of consumers. Based on the book by Deborah Blum, The Poison Squad tells the story of government chemist Dr. Harvey Wiley who, determined to banish these dangerous substances from dinner tables, took on the powerful food manufacturers and their allies. Wiley embarked upon a series of bold and controversial trials on 12 human subjects who would become known as the "Poison Squad." Following Wiley's unusual experiments and tireless advocacy, the film charts the path of the forgotten man who laid the groundwork for U.S. consumer protection laws, and ultimately the creation of the FDA.

Part One chronicles Bush's unorthodox road to the White House. The once wild son of a political dynasty, few expected Bush to ascend to the presidency. Yet 36 days after the November 2000 election, Bush emerged the victor of the most hotly contested race in the nation's history. Little in the new president's past could have prepared him for the events that unfolded on September 11, 2001. Thrust into the role of war president, Bush's response to the deadly terrorist attack would come to define a new era in American foreign policy.