The Fly Team leads an international manhunt when an American woman and her new husband flee from Baltimore to Istanbul with her young son after a heinous murder. Also, Vo partners up with Special Agent Riley Quinn, who was not only sent to Budapest to work her first big case alongside The Fly Team but to also clandestinely investigate a member of the team.

After a young American woman is brutally murdered in Venice, the Fly Team is met with hostility when they discover that their person of interest has ties to a well-connected Italian family. Soon, the case gets even more complicated when the CIA Station Chief shows up with an agenda of his own. Meanwhile, pressure mounts on Quinn to deliver intel on Mitchell.