In Memphis, the tragic murder of 6 people in the same house on Lester Street tears a family apart. In Tulsa, the strange disappearance of a former Navy vet finally provides answers after almost 2 years. And in Atlanta, the brutal shooting of a young engaged couple on the side of the road haunts investigators.

Four of The First 48's female homicide detectives are highlighted in four condensed stories: in Memphis a confrontation turns deadly, in Cincinnati a single mother is torn between work and home, in Tulsa a family dispute takes a dark turn, and in Atlanta an interrogation room interview turns emotional.