Three homicide cases that examine how and why some women kill. In Tulsa, a woman is shot just outside her home and detectives are shocked by their suspect. In Birmingham, a mother of three is shot in front of her young children. And in Charlotte, when a couple is suspected of stabbing a man in his car, detectives need to determine who is telling the truth.

Homicide suspects go on the run to avoid the consequences of their actions; the police search for two gunmen responsible for a mass shooting; investigators worry an escaped convict might flee the country; a robbery goes awry.