In Harris County, Texas investigators are called to an abandoned SUV, its interior covered in blood. The vehicle's owner, a 20-year-old single mother, is nowhere to be found. The Sheriff's department believes she's been murdered, and her boyfriend is the main suspect--but he's not talking. Thirteen hundred miles away an SUV slams into a house, its driver shot dead behind the wheel. Detectives soon have an ID on his shooter, but he's fled the state, and a manhunt is on.

In Birmingham Alabama a mother of a two-year-old boy is found stabbed to death in her own bedroom. Investigators have a mystery on their hands when they learn the killer opened the victim's front door with a key and stole her diamond ring. In Cleveland Ohio, two 19 year-old men are shot and killed during a party at an abandoned house. All signs point to a good friend of the victims' as the shooter but no one actually saw him pull the trigger. With no DNA or murder weapon found, the state needs to convince a jury the defendant is a cold-blooded killer.