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Starsky and Hutch race against time while searching for an international hit man carrying a deadly virus.
Reporter Chris Phelps rides along with Starsky and Hutch in order to research an article on "the counter-culture cops, the new breed," as they investigate pushers that are cutting their drugs with strychnine.
As Hutch lies ill, Starsky resorts to a televised plea to urge the carrier of a fatal disease to surrender.