At Newham Hospital Emergency Department, a drunk man with knife wounds in his chest and hand refuses to cooperate, until heavy bleeding threatens his vital organs. In Belfast's Royal Victoria A&E, an 81-year-old woman has suffered a brutal injury to her leg from slipping in her muddy garden and smashing her shin into a concrete bar.

An aggressive male patient is rushed into Newham Hospital Emergency Department in East London, while shouting and swearing at doctors. Police are forced to physically restrain him, while Dr Nick and a team of clinicians try to determine what's wrong. Dr Sarah assesses 36-year-old David for a significant facial wound and swelling around his eye socket.