As winter drags on Charles, Dr. Pol and the rest of clinic staff brave the frigid temperatures to keep animals healthy in the clinic and on the farm. The first stop is an organic farm where the owner recently lost two calves to a mysterious infection. Across town, Dr. Brenda is called out to visit a 10-month-old horse who has cut his leg badly on a rusty trailer. Later, Dr. Pol and Charles investigate two bizarre cases, both involving birth defects at the opposite ends of two young calves!

After a long, cold winter, the animals of Isabella County are getting testy. Dr. Pol and Charles head out on a farm call to treat an angry bull with a deadly case of bloat. Dr. Pol must act quickly, or the bloat could block the bull's diaphragm and lead to death. Back at the clinic, a cat injured while birthing kittens inspires Charles to volunteer at HATS, the Humane Animal Treatment Society, whose goal is to keep the animal population in check by way of spaying and neutering animals.