After ten years away, Mark Kane and his daughter, Eleanor, return home to New York City, hoping to find a cure for a rare affliction. Meanwhile their neighbor Naomi Cole, an NYPD Homicide Detective, tries to balance investigating a brutal murder at work with raising her son Isaiah, whose newly sober father has suddenly come back into their lives. Claire Logan, a brilliant scientist, receives a devastating call from her estranged father, summoning her home.

Upon learning that Naomi is a homicide detective, Mark covers the tracks of his most recent crime. Eleanor discovers that Isaiah is being bullied at school and seeks revenge. Naomi and her partner Ben make a massive discovery in their case, but it comes at a cost. Meanwhile, Claire is on the brink of a major breakthrough in her own right.