Reese and Finch are caught in a power struggle for control of the city's gangs when Elias is targeted by Dominic, the ambitious leader of the Brotherhood. Meanwhile, Root and Shaw disagree over how to handle a new threat from Samaritan.

Samaritan launches a cyber-attack on the stock exchange, leaving the team with no choice but to embark on a possible suicide mission in a desperate attempt to stop a global economic catastrophe.