The team must unravel a conspiracy and stay ahead of the Secret Service when the President of the United States becomes their newest POI. Also, Finch separates himself from the team and considers taking drastic action to combat Samaritan.

As Finch's virus spreads, destroying both Samaritan and the Machine, Samaritan makes one last desperate attempt to preserve itself and the team undertakes one last mission to stop it... and not everyone will survive.