Few months after the end of the glee club, New Directions alumni are adjusting to their new lives in the Big Apple: Blaine and Sam have moved in with Kurt, while Artie experiences difficulties navigating the mean streets of Manhattan. Also, Rachel gets accustomed to being a Broadway star, and Mercedes moves to New York to work on her album.

When the boys get tested for STDs, Artie tests positive for a disease and he's forced to tell his sexual partners. Meanwhile, Kurt and Blaine have relationship issues when Blaine puts on his "freshman fifteen".