In the first episode of LOL: Who Laughs Is Out, the 10 comedians enter the theater. Fedez, conductor and referee, explains the rules of the game and starts the race. He and Frank Matano will follow the various stages of the challenge and point out who laughs. The challengers begin to "hit" each other with jokes and sketches but staying serious becomes more difficult for someone than expected ...

On the third episode, the contestants of LOL reveal their most hidden qualities: Virginia and Corrado get in contact with the spirit world, Forest shows off as an advertising spokesman, while Maria turns out to be a stellar majorette. Keeping a straight face isn't that easy, in fact, Fedez has to stop the game several times to show the yellow card.