The justification for Nick to become a Grimm again is made much clearer in the wake of the most recent attack against Monroe and Rosalee. At work, Nick and Hank are called to a stretch of highway that acts as a staging area for a horrifying Wesen ritual. In Vienna, Viktor meets with a completely broken Adalind, now ready to be of assistance in finding and retrieving the baby. Meanwhile, Trubel is surprised by the sudden arrival of an old friend.

An unsuspecting traveler brings a blood-sucking legend with him to Portland, and Nick and Hank find themselves investigating the gruesome trail of "El Chupacabra." Meanwhile, Monroe and Rosalee prepare to leave for their long-overdue honeymoon as they are met with more threats regarding their marriage. Elsewhere, Viktor and Adalind decide to take a trip of their own, while Wu decides to confront Nick about what he has been seeing.