Nick and Hank investigate a pair of murders that lead them to a family inflicted with a Wesen genetic disorder. Meanwhile, Renard arranges a meeting with Adalind, and Eve continues her investigation into Andrew's assassination.

A preacher uses his Devil-like Wesen form to convince his audience that he is possessed by Satan and then casts him out. While Nick and Hank investigate, Eve gets closer to Rachel than she expected when she disguises herself as Renard.