After a hotel guest kills a man on the street, Nick and Hank investigate and discover a series of bizarre murders and suicides at the same hotel. Meanwhile, Eve and Rosalee try to work out the meaning of the symbols,and Renard gets a warning about a visitor.

When a scientist is killed in her laboratory, Hank and Wu investigate and discover that a strange incident ties together the dead woman with three of her colleagues. Meanwhile, the black-skulled creature attacks Eve, and Nick stands guard over her as she recovers in the hospital.