In suburban Nebraska, a group of partying high school teens jokingly dare their friend Charlie to look into the mirror and repeat "Bloody Mary, Bloody Mary, Bloody Mary," not knowing this will unleash a series of mysterious murders. Sam and Dean realize that Bloody Mary has the power to travel through all reflective surfaces when she is hunting a victim. Worried that teens are accidentally summoning Bloody Mary, Sam and Dean race to destroy the violent spirit before she can kill again.

The infamous "Hook Man," a vengeful spirit who kills his victims with a shiny hook that serves as his hand, terrorizes a small college town in Iowa. Sam and Dean learn that all the victims are connected to the daughter of a local minister and race to find and destroy the Hook Man¿s bones before he comes for them.