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Sam and Dean try to come up with a way to rescue Lucifer and discover Chuck's plan to deal with Amara. Meanwhile, a new Prophet is awakened, but he's less than thrilled at the promotion.
The brothers investigate a murder-suicide in Colorado that may be tied to Amara. Meanwhile, Metatron receives a request to edit a new book.
To defeat Amara, Sam and Dean will first have to help Chuck and Lucifer reconcile. Once they do, they then must gather the forces of Heaven, Hell, and Magic to weaken Amara so that Chuck can defeat her. However, everything doesn't go quite according to plan.
The 11th season of this supernatural series begins with the Winchesters dealing with repercussions of releasing The Darkness on Earth. Sam and Dean Winchester are approached by a young deputy sheriff, Jenna, who reveals that people have been going rabid and starting killing sprees. Can the violent infection be cured?