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Sam and Dean battle a part-vampire/part-ghoul creature that is trying to raise an army to fight the coming Darkness. Meanwhile, Sam receives another cryptic vision, and the Impala witnesses everything.
When the Winchesters learn of demons killing witches, they approach one and have her find them Rowena so that they can have her cure Castiel. Meanwhile, Crowley raises the young Amara in Hell but soon discovers that the Darkness may be beyond his control.
Sam and Dean track down a double axe-murder at Lizzie Borden's home, and soon realize that something supernatural is involved. As they continue their investigation, they soon discover that Amara is responsible for creating an army of soulless killers.
The 11th season of this supernatural series begins with the Winchesters dealing with repercussions of releasing The Darkness on Earth. Sam and Dean Winchester are approached by a young deputy sheriff, Jenna, who reveals that people have been going rabid and starting killing sprees. Can the violent infection be cured?