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After the Darkness passes over them, Sam and Dean wake up and Dean realizes that he encountered the creature at the heart of the storm. Meanwhile, Castiel prays to Heaven to help him, and Crowley takes steps to avoid Castiel.
While Sam tries to find a cure for the Darkness virus invading his body, Dean takes Jenna to her grandmother's. Meanwhile, the angels torture Castiel for Metatron's information, and Crowley learns of the Darkness.
The 11th season of this supernatural series begins with the Winchesters dealing with repercussions of releasing The Darkness on Earth. Sam and Dean Winchester are approached by a young deputy sheriff, Jenna, who reveals that people have been going rabid and starting killing sprees. Can the violent infection be cured?