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The Winchesters investigate a series of mysterious disappearances every 27 years, and run into a pair of hunters where one is looking for revenge against the creatures that took his brother.
Sam and Dean try to convince Crowley to turn over the Horn of Joshua before destroying Lucifer--and Castiel--rather than after they use the Horn to defeat Amara. Meanwhile, an unexpected ally helps Amara heal from her injuries, and Lucifer makes the angels in Heaven an offer they can't refuse.
The brothers investigate a murder-suicide in Colorado that may be tied to Amara. Meanwhile, Metatron receives a request to edit a new book.
The 11th season of this supernatural series begins with the Winchesters dealing with repercussions of releasing The Darkness on Earth. Sam and Dean Winchester are approached by a young deputy sheriff, Jenna, who reveals that people have been going rabid and starting killing sprees. Can the violent infection be cured?