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While Sam and Castiel investigate a small Arkansas town where a teenager's head exploded, Dean takes Jack to see Donatello so they can find out what being without a soul feels like.
The hunt for a new monster goes awry when Dean is knocked unconscious, releasing Michael from his imprisonment. The archangel seeks out a new host body, and only one person can stop him.
While Sam and Dean go on a monster hunt against a monster that they can find out little about, Jack makes new friends with the local Lebanon teenagers but things go horribly wrong.
When Sam and Dean join forces with an unexpected ally, the outcome will alter the course of two lives. Meanwhile, Heaven faces an attack from a dark force, driving Castiel to make an enormous sacrifice to make things right.