Bracing themselves for the possibility of an apocalyptic war, Sam and Dean realize they have an enormous task of hunting down the hundreds of demons that escaped from the Devil's Gate. With only a year left to live, Dean decides to live life to the fullest and exhibits a carefree attitude that troubles Sam, who is trying to find a loophole in the deal. Bobby tells the brothers about a sighting in Nebraska that turns out to be seven demons that are the actual manifestations of the Seven Deadly Sins.

Sam and Dean answer a call on their dad's old cell phone, alerting them someone has broken into John's secret storage room in New York. They discover a cursed rabbit's foot has been stolen and call Bobby for help. He advises them to beware of the foot because anyone who touches it will receive an extreme amount of good luck, but once the foot is lost that person will die. Unfortunately, Sam has already handled the foot, which causes an overjoyed Dean to buy lottery tickets, but a female thief steals it from Sam causing his luck to plummet and putting his life in danger.