Ruby tells Sam and Dean that a powerful demon named Alastair is searching for a girl named Anna who can hear the angels' conversations. The three set out to find Anna but once they do, Alastair attacks them and Ruby escapes with the girl. Believing they were set up, Dean lashes out at Sam for trusting Ruby, so Sam tells him what happened during those months Dean was in Hell and how Ruby saved his life. Castiel and Uriel return and demand to be taken to Anna but not for the reason Dean thinks.

Sam and Dean investigate the appearance of a young female ghost in an abandoned house, but things become more complicated when a family moves in. The brothers fail to get the family to leave, but when the son is kidnapped though the walls, they look to Sam and Dean to rescue the boy.