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While on a hunt, Sam runs into someone from his past and a confrontation ensues. Meanwhile, Dean reluctantly teams up with a quirky, laid-back hunter named Garth, when he finds himself in a situation that he just cannot explain.
Sam and Dean investigate the gruesome murders of resident mediums in Lily Dale, the most "psychic" town in America. They discover that an angry spirit is killing off the psychics one by one, but in a town full of people who claim to be summoning spirits, they have a little trouble identifying the medium controlling the ghost.
Sam, Dean and Bobby become actual hunters, in the true sense of the word, when they set up camp in a New Jersey state park to track a creature that has been attacking people in the woods. The townsfolk claim it is the real Jersey Devil. Meanwhile, Dean is beyond thrilled to find a Biggerson's restaurant in town, but is devastated when he discovers the restaurant's special sandwich seems to be making people crazy.
In season seven, the events take place right after the angel Castiel absorbed the souls of Purgatory declares himself as the new God. And the "mutated angel" goes around the planet to try and finish his "work". But eventually, thanks to a little bit of help from the Horseman Death, Winchesters convince the angel to return all the souls back to Purgatory. But Castiel manages to return all but the souls of some older creatures. Something in which the Winchesters will find themselves in an increasingly sinister, changing landscape, as they go up against this new foe, which is unlike anything they've ever fought before: the Leviathans, the very first beasts created by God Himself, but were then locked away in Purgatory for being too destructive. They brothers will find their old tricks, weapons and hiding places all rendered useless. All they'll have is each other. And the certainty that, like the last of the cowboy outlaws, whatever they face, they're not going down without a fight.