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Eph and Nora finally see their lethal virus in action. Fet takes the security of Red Hook into his own hands while Dutch and Setrakian set off for Staten Island to question Fitzwilliam, Palmer's former bodyguard.
Gus and Vaun wage an attack on Palmer as Eph struggles to connect with Zack. Councilwoman Justine Faraldo vows to bring her extermination policies to the other boroughs.
Eph changes his appearance to leave the city while Nora is left as the reluctant parent for Zack. Dutch and Nora make a deal with Justine to secure Fet's release from jail.
The virus has reached epidemic levels in season two as the Master seeks revenge. Eph and Dr. Nora Martinez work on a weapon to destroy the creatures, while Abraham Setrakian searches for a book that may hold the secrets to ending the infected.