After the horrifying revelations and reversals of fortune in Baltimore, Chandler and his fractured team join forces with an underground resistance in an attempt to defeat Amy Granderson. With doses of the cure running low, Rachel tries to do some good for the sick while remaining a prisoner at Avocet. Meanwhile, Slattery and the crew of Nathan James are in a race against time to save an injured Dr. Tophet and regain control of their ship.

Nathan James returns home to Norfolk on a mission to produce and mass distribute the cure. With his family now safely aboard the James, Chandler sends his crew in search of their own friends and loved ones. Who, if any, will find their families? And will those who do return to the ship?.