When a member of the security detail for an upcoming Aid Summit is murdered before he can reveal the details of an assassination plot, Five-0 is brought in to investigate the murder and protect the target, a ruthless dictator.

While Five-0 investigates the murder of a man on his honeymoon and his wife's abduction, Medical Examiner Dr. Max Bergman recognizes uncanny similarities to a series of unsolved homicides from a year ago.