When a tourist is killed after unknowingly transporting a stolen Van Gogh, an undercover Kono and Chin enter the world of black market priceless art and are taken hostage. Also, McGarrett asks Iron Chef Masaharu Morimoto to help train Kamekona to beat Chef Sam Choy in a shrimp cook-off.

A patient infected with a contagious and lethal strain of bird flu is kidnapped and the culprits intend to weaponize the virus.