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When investigating a deserted yacht adrift at sea, McGarrett, Danny, Tani, and Junior are exposed to a deadly bioweapon and the rest of Five-0 have only eight hours to find an antidote.
McGarrett poses as a pilot to investigate the cause of a plane crash that led to the death of a pilot in an air race.
When Danny is shot while quarantined in the hospital with McGarrett, Tani, and Junior, he's left unconscious and clinging to life, imagining a future for everyone in Five-0.