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President Ellis sanctions Coulson to continue leading S.H.I.E.L.D. to deal with the Inhuman power. Meanwhile, Malick discovers that his new guest can speak, and Daisy's team encounters two new Inhumans in Bogota.
Mack and his team invade the Hydra castle in the hopes of bringing Fitz and Coulson back through the portal. Meanwhile, on the alien world Grant's team find Will and Fitz convinces him to lead them to the extraction point.
Coulson and a reluctant Talbot attend an international symposium on the Inhumans, and discover a traitor in their midst. Meanwhile, the team meets Talbot's new bodyguard, who may provide a vaccine against Terrigenesis.
Marvel's Agents of S.H.I.E.L.D. returns for an action-packed third season, with Director Phil Coulson and Agent Daisy Johnson leading the charge as S.H.I.E.L.D. searches the world for more powered people in the aftermath of their epic battle with Jiaying and her army of Inhumans. However, Coulson and the team soon find out that they are not the only group looking for these new Inhumans.