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The CDC team continue to investigate the island; at the same time, they discover Peter's brother, Alan, is a member of Brother Michael's cult, and his warnings for them to leave the abbey fall on deaf ears.
In the second-season premiere, Drs. Peter Farragut and Sarah Jordan are joined by Kyle Sommer when they battle a new deadly virus on a mysterious wooded island.
Jordan and Peter travel outside the safety of the abbey to retrieve some specimens and discover just what's living in the woods; at the same time, Sister Amy plots to make the CDC team leave forever.